Sepsis-3 Definitions

Raising concerns about the Sepsis-3 definitions

The Global Alliance for Infections in Surgery appreciates the great effort of the task force who derived and validated the Sepsis-3 definitions and considers the new definitions an important step forward in the evolution of our understanding of sepsis. Nevertheless, more than a year after their publication, we have a few concerns regarding the use of the Sepsis-3 definitions.

Sepsis definitions

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

IMPORTANCE Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the pathobiology (changes in organ function, morphology, cell biology, biochemistry, immunology, and circulation), management, and epidemiology of sepsis, suggesting the need for reexamination. OBJECTIVE To evaluate and, as needed, update definitions for sepsis and sept...

Evaluation of definitions for sepsis.

OBJECTIVE To evaluate the current definitions for sepsis and clarify and quantify the risk for intensive care unit (ICU) patients with sepsis. DESIGN A prospective cohort analysis of 519 patients with a primary clinical diagnosis of sepsis treated in the ICUs of 40 US hospitals drawn from a nationally representative sample of 17,440 admissions. MEASUREMENTS Patient's age, treatment location...

Sepsis definitions: time for change.

For the Ancient Greeks, sepsis referred to rot, decay, or putrefaction. Galen and Celsus described the signs of infl ammation as peripheral vasodilatation (rubor), fever (calor), pain (dolor), increased capillary permeability (tumor), and organ dysfunction (functio laesa). The modern concept of sepsis has focused on the human response to invading organisms. In 1991, a North American consensus c...